2015
Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes.
Journal of virology
•Research at a glance
Top areas of exploration
- B-Lymphocytes , 11 publications
- Cell Line, Tumor , 9 publications
- Virus Activation , 9 publications
- STAT3 Transcription Factor , 8 publications
Research activity
Focus
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
My publications
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54 publications
2015
STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus.
Journal of virology
•2014
B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation.
Journal of virology
•2014
Human B cell immortalization for monoclonal antibody production.
Methods in molecular biology (Clifton, N.J.)
•2014
Serum IgA to Epstein-Barr virus early antigen-diffuse identifies Hodgkin's lymphoma.
Journal of medical virology
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