2014
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America
•Research at a glance
Top areas of exploration
- B-Lymphocytes , 11 publications
- Cell Line, Tumor , 9 publications
- Virus Activation , 9 publications
- STAT3 Transcription Factor , 8 publications
Research activity
Focus
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
My publications
Filter publications
54 publications
2013
Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.
Journal of virology
•2011
Establishment of Epstein-Barr virus growth-transformed lymphoblastoid cell lines.
Journal of visualized experiments : JoVE
•2011
Identification of a sub-population of B cells that proliferates after infection with Epstein-Barr virus.
Virology journal
•2010
Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitors.
Journal of virology
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