2018
KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human Herpesviruses.
Journal of virology
•Research at a glance
Top areas of exploration
- B-Lymphocytes , 11 publications
- Cell Line, Tumor , 9 publications
- Virus Activation , 9 publications
- STAT3 Transcription Factor , 8 publications
Research activity
Focus
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
My publications
Filter publications
54 publications
2017
Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells
PLOS Pathogens
•2017
Engineering Structurally Interacting RNA (sxRNA).
Scientific reports
•2016
A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases.
Frontiers in microbiology
•2016
Anti-TNFα therapy for inflammatory bowel diseases is associated with Epstein-Barr virus lytic activation.
Journal of medical virology
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