2020
STAT3 activates the anti-apoptotic form of caspase 9 in oncovirus-infected B lymphocytes.
Virology
•Research at a glance
Top areas of exploration
- B-Lymphocytes , 11 publications
- Cell Line, Tumor , 9 publications
- Virus Activation , 9 publications
- STAT3 Transcription Factor , 8 publications
Research activity
Focus
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
My publications
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54 publications
2020
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes
PLOS Pathogens
•2019
Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesviruses.
Virus evolution
•2019
Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes
PLOS Pathogens
•2019
Retrograde Regulation by the Viral Protein Kinase Epigenetically Sustains the Epstein-Barr Virus Latency-to-Lytic Switch To Augment Virus Production.
Journal of virology
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