2020
A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents
Journal of Virology
Research at a glance
Top areas of exploration
- B-Lymphocytes , 11 publications
- Cell Line, Tumor , 9 publications
- Virus Activation , 9 publications
- STAT3 Transcription Factor , 8 publications
Research activity
Focus
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
My publications
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54 publications
2020
A promiscuous inflammasome sparks replication of a common tumor virus
Proceedings of the National Academy of Sciences
•2020
Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus.
Journal of virology
•2020
Post Transplant Lymphoproliferative Disorder risk factors in children: Analysis of a 23-year single-institutional experience.
Pediatric transplantation
•2020
Selective Targeting of Virus Replication by Proton Pump Inhibitors.
Scientific reports
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