2021
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Blood
•Research at a glance
Top areas of exploration
- B-Lymphocytes , 11 publications
- Cell Line, Tumor , 9 publications
- Virus Activation , 9 publications
- STAT3 Transcription Factor , 8 publications
Research activity
Focus
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
My publications
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54 publications
2021
A heterochromatin inducing protein differentially recognizes self versus foreign genomes
PLOS Pathogens
•2021
An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles.
Frontiers in microbiology
•2021
Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus
Viruses
•2021
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency
Journal of Virology