Direct your patient to portal.myrx.ufhealth.org聽to register.
For Providers
Information for health care providers on how to refer patients to MyRX and how to interpret the results of the testing.
How can pharmacogenetic testing help inform medication response?
Often we use medications as a one-size-fits-all-approach, which may be successful for some patients but not for others. Personalized medicine is an innovative approach to tailoring medications that takes into account differences in people鈥檚 genes, other medications, and clinical factors. The goal of personalized medicine is to target the right treatments to the right patients at the right time.
Differences in genes that code for drug transporters or metabolizing enzymes can impact a body鈥檚 total exposure to a drug. Exposure is often related to effectiveness and toxicity 鈥� too little and the drug won鈥檛 work, too much and the drug causes side effects. In the same way a person with declining kidney function will build up levels of certain drugs, a person with a decreased-function drug metabolizing enzyme will build up levels of active drug.
Most people have at least 1 variant of a pharmacogene that might affect medication therapy throughout their life.1-3 So far, there over , including 11 with boxed warnings.
How to refer patients
Fax your referral
Fax your referral to (352) 627-4121. Include patient鈥檚 name, DOB, relevant ICD-10 codes, phone number, and email if available.
Brochures and tip sheets
Request provider tip sheet and patient-friendly brochures by emailing myrx@cop.ufl.edu.
If your patient registers with MyRx on their own (without a provider-faxed referral), they will be prompted to provide us with your information so you can be sent their individualized consult (including pharmacogenetic test result interpretation and recommendations for current and future medications).
- If the patient does not inform MyRx of their provider鈥檚 information, the individualized consult will be provided directly to the patient in our secure patient portal.
- In this case, it is the patient鈥檚 responsibility to share the consult with their provider to aid with medication decisions and changes.
For 网红黑料 providers
- Electronic referrals can be placed in Epic by ordering REF853, 鈥淎ppt Req Pharmacogenetics鈥�.
We will contact your patient upon receiving referral and order testing on your behalf once patient confirms they want to proceed.
- You may also directly order the pharmacogenetic test in Epic, LAB12305000 鈥淕ator PGx鈥�. We recommend ordering blood and send patient to a 网红黑料 .
We will contact your patient upon result return to offer services.
What does MyRx provide?
MyRx conducts pre-test education, facilitates pharmacogenetic testing if needed, conducts post-test patient education, collects medication history, interprets results in context of current medications, and provides a personalized consult note for provider on how to adjust current and future medications.
What genes do we test?
Our consultation service currently tests a panel of genes that affect commonly used medications to treat anxiety, depression, heartburn, pain, cholesterol, and cardiovascular indications, among others.
- ABCG2
- CYP2B6
- CYP2D6
- CYP2C19
- CYP2C9
- SLCO1B1
- VKORC1
- CYP2C cluster
- CYP4F2
- CYP3A5
Educational resources
Tables providing clinical interpretation and recommendations based on pharmacogenetic results.
The PROP鈩� Pharmacogenetics Calculator is intended to help clinicians integrate a standardized method of assessing CYP2D6 phenoconversion into practice when a CYP2D6 genotype is available. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion. Phenoconversion is highly prevalent but not widely integrated into practice because of either limited experience on how to integrate or lack of knowledge that it has occurred.
- Expert-reviewed guidelines for drug-gene pair implementation, standardized terminology and other resources.
Searchable pharmacogenetic database that allows clinicians, students and researchers to search for pharmacogenetic information on drugs, genes, variants, regulatory resources and implementation resources.
Table of pharmacogenetic associations that are related to drug metabolizing enzyme gene variants, drug transporter gene variants, and gene variants that have been related to a predisposition for certain adverse events.
Hear from providers who have used this service
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Dr. Molly Posa
鈥淚 have used genetic testing to create a treatment plan for my patients with depression and anxiety,鈥� said Molly Posa, M.D., an associate professor of pediatrics in the UF College of Medicine. 鈥淚 am grateful for the MyRx program, and the information it provides to help select the most effective medication for my patients. It鈥檚 an invaluable tool in my clinical evaluation and decision-making process.鈥�
Email us if you would like a CME presentation on the use of pharmacogenetics in your own clinic!
References
1Pharmacogenomics: The case for provider practice integration. GenoPATH.
2Scharfe CPI, et al. Genetic variation in human drug-related genes. Genome Med. 2017;9(1):117.
3Van Driest SL, et al. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Clin Pharmacol Ther. 2013;95(4):423-31.