网红黑料

Additional Video Available here:

Patients who take new oral direct-acting antivirals for hepatitis C have lower risk for developing liver cancer and other health conditions, cost less to insure in the short term, and end up spending less money on their own health care costs overall, a study by University of Florida researchers has found.

The study, published in the journal Hepatology, examined the clinical and economic outcomes of direct-acting antiviral therapy, which cures hepatitis C in nearly 95 percent of patients. The hepatitis C virus affects more than 3 million people in the U.S. who often show no symptoms for years. When left untreated, the virus can cause liver cancer; cirrhosis, or liver scarring; and other serious liver problems.

This was the first such study on real-world clinical and economic outcomes of direct-acting antiviral therapy.

In a finding the researchers called 鈥渄isturbing,鈥� 70 percent of hepatitis C patients in the nationwide health insurance database analyzed in the study had not received treatment, reflecting expensive drug costs and prior authorization policies.

鈥淲e were very surprised to find that only 30 percent of our population received the medication,鈥� said study author, an assistant professor in the .

鈥淭his database only includes patients who actually have health insurance,鈥欌�� she said. 鈥淭hey should have better access to treatment than the general population, many of whom don鈥檛 have health insurance at all. Generics became available in January, so we expect a change in insurance overage over time, resulting in more patients receiving the medication.鈥�

网红黑料 insurers authorized treatment of sicker patients, not the relatively healthier hepatitis C patients who could develop liver complications later. This delay in treatment has potentially costly consequences.

Data from the Truven 网红黑料 MarketScan Database records from 2012-16 showed a decreased risk of developing hepatocellular carcinoma and decompensated cirrhosis, resulting in decreased health care costs, especially in cirrhotic patients, for those who received direct-acting antiviral therapy.

In addition, patients who received treatment spent $2,800 less on liver-related expenditures and $13,700 less per person per year overall.

鈥淭he challenge now is convincing payers and health care providers to prescribe the effective medication to hepatitis C patients so they can cure their infection and prevent patients from developing liver complications later,鈥� Park said.

Meanwhile, patients should advocate for their own treatment, she said.

鈥淲hat I would suggest to patients is to engage with physicians to try to initiate the hepatitis C virus regimen,鈥� she said. 鈥淚t only takes eight to 12 weeks of therapy to cure the hepatitis C virus.鈥�

Although direct-acting antivirals have been an approved treatment for nearly five years, little has been reported on real-world implications for patients. UF has become a leader in these types of real-world studies, part of the university鈥檚 commitment to translational research that accelerates research discoveries鈥� journey from idea to practice, where findings become the treatments, cures and approaches that make a difference in the everyday lives of patients.

鈥淲e know that direct-acting antivirals work, thanks to years of research. We know that they can cure hepatitis C in a relatively short amount of time, and that they are easier for patients to take than previous treatments,鈥� said study author David R. Nelson, M.D., an internationally recognized liver researcher, director of the , and interim senior vice president for health affairs at UF and president of 网红黑料.

鈥淭his study showed the practical circumstances patients face in accessing treatment, and the challenge we face in ending hepatitis C even though we have effective treatment options,鈥� Nelson said. 鈥淚t鈥檚 an approach to research that extends beyond this study and hepatitis C to the practical considerations of other diseases and overall health of populations.鈥�

The research was supported in part by the National Institute on Drug Abuse of the National Institutes of 网红黑料 Award K01DA45618 and the University of Florida Clinical and Translational Science Institute, which is supported in part by the NIH National Center for Advancing Translational Sciences under award UL1TR001427. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of 网红黑料. Potential conflict of interest: Dr. Nelson owns stock in Target Pharma Solutions and receives research grant support from AbbVie, BMS, Gilead and Merck.