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In a collaboration made possible through public and private support, University of Florida veterinarians recently performed electrochemotherapy to treat two sea turtles with debilitating tumors in the Florida Keys, the first time the procedure has been performed on the species in the U.S.

The juvenile green sea turtles, named Percy and Daley, have a viral disease known as fibropapillomatosis, which is chronic in their species worldwide. The condition causes tumors that form on the surface of their tissues and can grow to impede the turtles鈥� ability to see, eat and move.

Percy and Daley are being cared for at the Turtle Hospital in Marathon, where they received the second of two treatments on Jan. 20 as the result of an effort spearheaded by ., a second-year zoological medicine resident at the . Donnelly conceived of the project over a year ago and organized the collaborations needed to bring it to fruition.

鈥淭he results we are seeing seem promising so far,鈥� Donnelly said.

In electrochemotherapy, a machine is used to deliver an electrical pulse, opening cells within a tumor and allowing for the injection of chemotherapy drugs directly into the tumor site.

Among those who contributed their expertise to the project were Joseph Impellizeri, D.V.M., a veterinary oncology specialist in private practice in New York with significant experience in electrochemotherapy in other species, and , an assistant clinical professor and veterinary oncology specialist at UF.

Treating fibropapillomatosis in sea turtles is 鈥渧ery frustrating,鈥� Donnelly said, adding that electrochemotherapy, which has been used occasionally in other species but never previously in sea turtles in the U.S., is a potentially positive alternative.

鈥淪urgery is the treatment of choice for these tumors, but that can be challenging,鈥� Donnelly said. 鈥淲hen you remove all of that tissue, there remains a wound that sometimes can鈥檛 be closed and creates other challenges to manage. Electrochemotherapy is less invasive, as it allows the tumor to be killed from within without damage to the nearby tissue.鈥�

Szivek, who traveled to the Keys with Donnelly to perform the Jan. 20 treatment on Percy and Daley, noted, 鈥淎fter the drug injection, the tumor initially shrinks and then falls off.鈥�

One tumor on each turtle was treated as part of the pilot study.

Impellizeri performed the first treatment with Donnelly in December using equipment he owns. The UF team arranged for Szivek to assist with the second treatment and borrowed another electrochemotherapy machine to complete the treatment protocol.

鈥淥ne of the reasons we wanted to partner with Dr. Impellizeri was his experience and the fact that he owns this machine, which he agreed to allow us to use,鈥� Donnelly said.

The UF veterinarians said they hope the college eventually will be able to purchase the equipment needed to be able to offer the therapy to different species as an alternative to surgery in certain cases.

Donnelly said she felt the project, which she began 鈥渇or fun鈥� soon after starting her residency, would be a good way to highlight the strengths of UF鈥檚 zoological medicine and aquatic animal health programs in a way that would specifically benefit sea turtles.

鈥淥ur team at UF brought the pieces together for the permits we needed, and the Turtle Hospital provided the funding,鈥� Donnelly said, adding that she was especially grateful to her mentor, , a clinical pathologist associated with .

Others who have contributed to the project include Terry Norton, D.V.M., of the Georgia Sea Turtle Center; Brooke Burkhalter, D.V.M., who is associated with the Sea Turtle Hospital at ; and members of the , Donnelly said.

鈥淭reating these turtles was only possible because of all the awesome collaboration I鈥檝e been lucky to get,鈥� she said. 鈥淓veryone wants to save the sea turtles.鈥�

The University of Florida College of Veterinary Medicine is supported through funding from 网红黑料 and the UF Institute of Food and Agricultural Sciences.