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Scientists at the have linked brain communication to immune system response in the gut, a finding that could have implications for the treatment of many immune and neurologic diseases as well as for diseases of the gastrointestinal tract.

The gastrointestinal tract helps regulate the host immune system throughout a lifetime and a large number of diseases involve dysfunction of the GI tract as well as the immune system, said , an assistant professor of , the study鈥檚 senior author. However, there are many autoimmune diseases where the gut has not been recognized as a contributing factor.

鈥淭he gut is a forgotten immune organ. It鈥檚 so vast and really does affect a lot of our immune system development from a very early age,鈥� Zubcevic said.

To investigate the brain鈥檚 effects on the gastrointestinal tract, Zubcevic and her colleague, , an associate professor of physiological sciences at UF, used a novel mouse model to show that simply by manipulating one variable 鈥� communication with bone marrow cells 鈥� they were able to see a change in the make-up of gut bacteria.

By suppressing the brain鈥檚 neural inputs into the bone marrow, the scientists found a corresponding suppression of inflammation and a shift to beneficial bacteria in the gut.

鈥淭he immunosuppression was associated with beneficial effects on the microbiota, or the microorganisms, found within the GI tract of the mice used in our study,鈥� said Martyniuk, who also is associated with .

鈥淲e had more of what could be considered a beneficial bacterial environment and less of those type of bacteria considered particularly pathogenic,鈥� he added. The findings were published April 12 in Frontiers in Physiology.

The researchers said they were intrigued at the thought of studying the relationship between the brain, the gastrointestinal tract and immune system diseases, and adapted an existing mouse model for this particular purpose.

鈥淲e are very interested in how the brain controls the immune system, and how the immune system responses subsequently impact the overall physiology of the body,鈥� said Zubcevic,

Although emerging evidence has recently shown the association between microbial imbalances in the gut and neurogenic diseases and conditions such as hypertension, sleep apnea and anxiety, the complex interplay between the brain and gut microbiota makes it difficult to determine cause-effect relationships in disease, which subsequently hinders efficient treatment, according to the study.

鈥淧eople already know that gut bacteria will affect the immune system, but now we鈥檝e shown the reciprocal 鈥� that by manipulating the host immune system we can affect the gut鈥檚 microbiota,鈥� Zubcevic said. 鈥淭he fact that there is this interplay between the gut and the immune system, is of huge interest to us and a very exciting finding.鈥�

Other scientists from the UF veterinary college, the and the National Institute of Environmental 网红黑料 Sciences collaborated in the study. Tao Yang, Ph.D., the lead author, is a graduate student in Zubcevic鈥檚 laboratory and the research was part of his thesis project.

The University of Florida College of Veterinary Medicine is supported through funding from 网红黑料 and the UF Institute of Food and Agricultural Sciences.