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Patients diagnosed with fibromyalgia complain of chronic pain throughout their bodies, but often doctors have difficulty detecting what causes the pain, and therefore, how to treat it.

These patients also complain of hyperalgesia, or increased sensitivity to pain. A University of Florida study published in the July issue of the European Journal of Pain has found that injections of the painkiller lidocaine in peripheral tissues such as muscles in the shoulders or buttocks reduced hyperalgesia, bringing researchers one step closer to understanding how chronic pain works within these patients.

鈥淲e hypothesized that if pain comes from the peripheral tissues, and we can take this pain away by injecting local anesthetics, then this would be indirect proof of the importance of peripheral tissues for the clinical pain of these individuals,鈥� said , M.D., a professor of medicine within the .

Sixty-two women diagnosed with fibromyalgia were involved in the study. Each woman received two injections in the trapezius muscles of the shoulders and the gluteal muscles of the buttocks, for a total of four injections per patient. The women were divided into several groups and given mechanical and heat pain stimuli immediately before and then 30 minutes after the injections. One group received four saline injections. The second group received four lidocaine injections.

Although the lidocaine injections significantly reduced hyperalgesia, the placebo injections did not. The study also found that the lidocaine and saline placebo injections both resulted in a 38 percent reduction in patients鈥� clinical pain, or the pain a person feels at the point of injury as well as pain radiating throughout the area near the injury. There was no statistical difference between the painkiller and the saline placebo.

Treatment of chronic pain is difficult because doctors often can鈥檛 detect evidence of injury at the site where patients experience pain, Staud said. But chronic pain affects the body differently than, for example, a single incident such as a leg break. It actually changes nerve function along patients鈥� spinal cords, said , Ph.D., director of the .

He said hyperalgesia is a phenomenon in which the nervous system becomes sensitized to stimulation, amplifying the intensity perceived by the patient. Knowing what kind of treatment is successful in treating this sensitivity could bring researchers closer to providing relief to patients 鈥� combating their hyperalgesia and curbing chronic pain.

鈥淭he best way to treat chronic pain conditions is multidisciplinary and multimodal, looking at emotional, sensory and tissue damage. We know there are central and peripheral and social and behavioral components to someone saying, 鈥極w, it hurts,鈥欌�� said Robinson, also a professor in the in the

For example, in a person with a history of cancer pain, even if the cancer has been treated and is in remission, experiencing new pain in the afflicted area can trigger associations with the pain surrounding the patient鈥檚 cancer, including fears about the patient鈥檚 prognosis and anxiety about treatment.

鈥淭hat sensation may well feel more painful than if they just thought it was a tweaked a muscle,鈥� Robinson said.

Staud said the study can help them develop better ways of managing chronic pain.

鈥淥ver-the-counter medications and prescriptions such as opiates aren鈥檛 really effective for controlling chronic pain conditions,鈥� Staud said. 鈥淲e are able to explain the pain of chronic patients better and manage it better. We are making progress but it will take time.鈥�