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In 1986, Friedman began collaborative work with Francis J. Bova, Ph.D., which led to the development of the patented UF radiosurgery system. The system, known as LINAC Scalpel, assists with localizing, planning and treating intracranial tumors using computer software and a specially designed linear accelerator. The LINAC Scalpel has become one of the most popular commercial radiosurgery systems worldwide and has improved the accuracy of high-dose radiation delivered to brain tumors, with very little of the dose reaching normal brain structures. Friedman and Bova received the 1990 UF College of Medicine Clinical Research Prize in recognition of this accomplishment. Friedman is the leader of a multidisciplinary radiosurgery team, which has treated more than 4600 patients, published more than 175 papers and chapters, produced many international meetings and educated hundreds of visiting physicians.