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Nikolaus McFarland, MD, PhD : Research

Neurologist

Photo of Nikolaus McFarland
(352) 294-5400 MyUFÍøºìºÚÁÏ

Research at a glance

Top areas of exploration

  • Parkinson Disease , 44 publications
  • Supranuclear Palsy, Progressive , 19 publications
  • Multiple System Atrophy , 15 publications
  • Parkinsonian Disorders , 13 publications

Research activity

97 publications

4,899 citations

Why is this important?

Focus

Dr. McFarland is a member of the Norman Fixel Institute for Neurological Diseases and the Center for Translational Research in Neurodegenerative Disease (CTRND), which aims to bring the bench research closer to the bedside. His research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and on identifying novel biomarkers for early detection and tracking of disease and therapeutic development. A primary goal of his research is to identify and to develop potential novel therapeutics for Parkinson disease and related disorders. His research extends also to the clinic where he is actively involved in multiple clinical trials for atypical Parkinson disorders and Huntington disease.

Active clinical trials

AMX0035 and Progressive Supranuclear Palsy

A35-009 (ORION) is a Phase 2b/3 trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of randomized, double blind placebo controlled phases, followed by an optional open-label…

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
40 Years - 80 Years
Sexes
All
ONO MAS

This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of multiple doses of ONO-2808 in patients with MSA. This is the first study of ONO-2808 in…

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
30 Years - 80 Years
Sexes
All
ROCHE HD
Investigator
Nikolaus McFarland
Status
Accepting Candidates

My publications

97 publications

2025

Peripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroidal anti-inflammatory drugs.

Neurobiology of disease

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2025

Peripheral immune cell response to stimulation stratifies Parkinson’s disease progression from prodromal to clinical stages

Communications Biology

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2024

A General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders

Neurology Clinical Practice

2024

Characterizing Disease Progression in Parkinson’s Disease from Videos of the Finger Tapping Test

IEEE Transactions on Neural Systems and Rehabilitation Engineering

2024

Peripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages.

bioRxiv : the preprint server for biology

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