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Nikolaus McFarland, MD, PhD : Research

Neurologist

Photo of Nikolaus McFarland

Research at a glance

Top areas of exploration

  • Parkinson Disease , 44 publications
  • Supranuclear Palsy, Progressive , 19 publications
  • Multiple System Atrophy , 15 publications
  • Parkinsonian Disorders , 13 publications

Research activity

97 publications

4,899 citations

Why is this important?

Focus

Dr. McFarland is a member of the Norman Fixel Institute for Neurological Diseases and the Center for Translational Research in Neurodegenerative Disease (CTRND), which aims to bring the bench research closer to the bedside. His research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and on identifying novel biomarkers for early detection and tracking of disease and therapeutic development. A primary goal of his research is to identify and to develop potential novel therapeutics for Parkinson disease and related disorders. His research extends also to the clinic where he is actively involved in multiple clinical trials for atypical Parkinson disorders and Huntington disease.

Active clinical trials

Kinect-HD2

This is a Phase 3, open-label study to evaluate the long-term safety and tolerability of valbenazine, and to provide participants continued access to valbenazine for the treatment of chorea associated with Huntington disease.

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
18 Years - 75 Years
Sexes
All
PPMI Clinical -Establishing a Deeply Phenotyped PD Cohort (PPMI)

The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease…

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
30 Years - N/A
Sexes
All
Enroll-HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America.…

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
18 Years - N/A
Sexes
All

My publications

97 publications

2000

Convergent inputs from thalamic motor nuclei and frontal cortical areas to the dorsal striatum in the primate.

The Journal of neuroscience : the official journal of the Society for Neuroscience

2000

Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum.

The Journal of neuroscience : the official journal of the Society for Neuroscience

1999

The concept of the ventral striatum in nonhuman primates.

Annals of the New York Academy of Sciences

1998

Genetic approaches to the detection of contaminants in Escherichia coli fermentations.

Biotechnology progress

1997

Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate.

The Journal of neuroscience : the official journal of the Society for Neuroscience