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Nikolaus McFarland, MD, PhD : Research

Neurologist

Photo of Nikolaus McFarland

Research at a glance

Top areas of exploration

  • Parkinson Disease , 44 publications
  • Supranuclear Palsy, Progressive , 19 publications
  • Multiple System Atrophy , 15 publications
  • Parkinsonian Disorders , 13 publications

Research activity

97 publications

4,899 citations

Why is this important?

Focus

Dr. McFarland is a member of the Norman Fixel Institute for Neurological Diseases and the Center for Translational Research in Neurodegenerative Disease (CTRND), which aims to bring the bench research closer to the bedside. His research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and on identifying novel biomarkers for early detection and tracking of disease and therapeutic development. A primary goal of his research is to identify and to develop potential novel therapeutics for Parkinson disease and related disorders. His research extends also to the clinic where he is actively involved in multiple clinical trials for atypical Parkinson disorders and Huntington disease.

Active clinical trials

AMX0035 and Progressive Supranuclear Palsy

A35-009 (ORION) is a Phase 2b/3 trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of randomized, double blind placebo controlled phases, followed by an optional open-label…

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
40 Years - 80 Years
Sexes
All
ONO MAS

This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of multiple doses of ONO-2808 in patients with MSA. This is the first study of ONO-2808 in…

Investigator
Nikolaus McFarland
Status
Accepting Candidates
Ages
30 Years - 80 Years
Sexes
All
ROCHE HD
Investigator
Nikolaus McFarland
Status
Accepting Candidates

My publications

97 publications

2021

The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism.

NPJ Parkinson's disease

•

2020

Automated MRI Classification in Progressive Supranuclear Palsy: A Large International Cohort Study.

Movement disorders : official journal of the Movement Disorder Society

•

2020

Current Management and Emerging Therapies in Multiple System Atrophy

Neurotherapeutics

•

2020

Early-Motor Phenotype Relates to Neuropsychiatric and Cognitive Disorders in Huntington's Disease.

Movement disorders : official journal of the Movement Disorder Society

•

2020

Introducing a Supportive Care Team for Advance Directive Education in a Neurological and Neurosurgical Patient Population.

Journal of patient experience

•