To find out the effect of Lu AF82422 on disease progression in participants with multiple system atrophy.
- Investigator
- Nikolaus McFarland
- Status
- Accepting Candidates
- Ages
- 40 Years - 75 Years
- Sexes
- All
Research at a glance
Top areas of exploration
- Parkinson Disease , 44 publications
- Supranuclear Palsy, Progressive , 19 publications
- Multiple System Atrophy , 15 publications
- Parkinsonian Disorders , 13 publications
Research activity
Focus
Dr. McFarland is a member of the Norman Fixel Institute for Neurological Diseases and the Center for Translational Research in Neurodegenerative Disease (CTRND), which aims to bring the bench research closer to the bedside. His research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and on identifying novel biomarkers for early detection and tracking of disease and therapeutic development. A primary goal of his research is to identify and to develop potential novel therapeutics for Parkinson disease and related disorders. His research extends also to the clinic where he is actively involved in multiple clinical trials for atypical Parkinson disorders and Huntington disease.
Active clinical trials
A35-009 (ORION) is a Phase 2b/3 trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of randomized, double blind placebo controlled phases, followed by an optional open-label…
- Investigator
- Nikolaus McFarland
- Status
- Accepting Candidates
- Ages
- 40 Years - 80 Years
- Sexes
- All
This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of multiple doses of ONO-2808 in patients with MSA. This is the first study of ONO-2808 in…
- Investigator
- Nikolaus McFarland
- Status
- Accepting Candidates
- Ages
- 30 Years - 80 Years
- Sexes
- All
My publications
Filter publications
97 publications
2012
Deep brain stimulation response in pathologically confirmed cases of multiple system atrophy.
Parkinsonism & related disorders
•2012
Encephalopathy, hypoglycemia, and flailing extremities: a case of bilateral chorea-ballism associated with diabetic ketoacidosis.
Tremor and other hyperkinetic movements (New York, N.Y.)
•2012
Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.
Brain research
•2011
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
Nature neuroscience
•2009
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Journal of neuropathology and experimental neurology
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