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This is a pilot study in a small number of children and young adults with relapsed/progressive medulloblastoma (MB) looking at the feasibility and safety of adoptive cell therapy plus PD-1 blockade.

Investigators

John A Ligon, Marcia B Hodik

Status

Accepting Candidates

Ages

4 Years - 30 Years

Sexes

All

The purpose of this study is to determine if the addition of infusions of a type of immune cell called a "natural killer", or NK cell to the sarcoma chemotherapy regimen GEM/DOX (gemcitabine and docetaxel) can improve outcomes in people with…

Investigator

John A Ligon

Status

Accepting Candidates

Ages

2 Years - 40 Years

Sexes

All

The purpose of this study is to evaluate the safety and efficacy of narsoplimab in pediatric patients with thrombotic microangiopathies (TMA) following hematopoietic stem cell transplant (HSCT).

Investigator

John A Ligon

Status

Accepting Candidates

Ages

28 Days - 17 Years

Sexes

All